| 专利名称 | Sulfated derivative Gastrodia elata polysaccharide, its manufacture and its use | 申请号 | JP2011528161 | 专利类型 | 发明专利 | 公开（公告）号 | JP5513510B2 | 公开（授权）日 | 2014.06.04 | 申请（专利权）人 | SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES | 发明（设计）人 | ディン、カン; キウ、ホン | 主分类号 | A61K31/737 | IPC主分类号 | A61K31/737; A61K36/18; A61P35/00; C08B37/00 | 专利有效期 | Sulfated derivative Gastrodia elata polysaccharide, its manufacture and its use 至Sulfated derivative Gastrodia elata polysaccharide, its manufacture and its use | 法律状态 | 说明书摘要 | The present invention discloses a sulfated derivative of polysaccharide extracted from gastrodia elata BL., the preparation method thereof and the use thereof in preparing antineoplastic medicaments, wherein, the gastrodia elata polysaccharide has the following structure : ± - D - GLc ?￠ p - 1 [ ?’ 4 - ± - D - Glc ?￠ p - ( 1 ] x ?“ 6 - { [ ?’ 4 ) - ± - D - Glc ?￠ p - ( 1 ] y ?’ 4 - ± - D - Glc ?￠ p - ( 1 ?’ } n - wherein, x and y are each an integer, and x + y = 16, "n" is and integer, and the mean molecular weight of the polysaccharide from gastrodia elata is estimated as 2.8 x 10 5 , the specific rotation of the polysaccharide is +95° in a 0.5 mg/mL aqueous solution thereof; the sulfated position is mainly at 6-hydroxy of the gastrodia elata polysaccharide, with mean molecular weight of 6.5 × 10 4 and a specific rotation of +150.0° in a 0.5 mg/mL aqueous solution thereof. In vivo and in vitro experiments indicate that the sulfated derivative of gastrodia elata polysaccharide can inhibit the tumor growth by suppressing the expression ofi Id1 to inhibit angiogenesis, and therefore has an obvious antitumor activity, and shows almost nontoxicity to endothelial cells, thereby having a good prospect of being developed into antineoplastic medicaments. |
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