| 专利名称 | Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof | 申请号 | US201414580509 | 专利类型 | US | 公开（公告）号 | US9452220(B2) | 公开（授权）日 | 2016.09.27 | 申请（专利权）人 | 中国科学院广州生物医药与健康研究院 | 发明（设计）人 | Zhang Yanmei;Ding Ke;Liao Jinxi;Wang Yican;Chen Panyu | 主分类号 | C07D239/94 | IPC主分类号 | C07D239/94;C07D403/12;C07D403/14;C07D405/12;C07D405/14;A61K47/48 | 专利有效期 | Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof 至Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof | 法律状态 | 说明书摘要 | The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof:;where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障