Bladder cancer tumor marker, antibody and use thereof

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专利名称 Bladder cancer tumor marker, antibody and use thereof 申请号 US201113814446 专利类型 US 公开(公告)号 US9073995(B2) 公开(授权)日 2015.07.07 申请(专利权)人 中国科学院生物物理研究所 发明(设计)人 Li Chong;Fan Zusen;Zhang Honglian;Dai Zhonghua;Tang Haidong;Chen Jun 主分类号 G01N33/53 IPC主分类号 G01N33/53;C07K16/00;C07K16/28;C07K14/705;G01N33/574;G01N33/68;C12N15/113;C12Q1/48;C12Q1/02;A61K47/48;A61K51/10;A61K45/06;A61K39/395;C07K16/30;C12N9/10 专利有效期 Bladder cancer tumor marker, antibody and use thereof 至Bladder cancer tumor marker, antibody and use thereof 法律状态 说明书摘要 Provided in the present invention are an aberrantly glycosylated integrin, AG-α3β1, and use thereof as a bladder cancer marker. Also provided in the present invention are a hybridoma cell generating an anti-AG-α3β1 monoclonal antibody, a monoclonal antibody BCMab1 secreted by the same, and use of BCMab1 in the preparation of a medicament for the treatment of bladder cancer. Also provided in the present invention is use of inhibitors of GAL3ST2 and N-acetylgalactosaminyltransferase 1 in the preparation of a medicament for the treatment of bladder cancer.

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