| 专利名称 | Method for preparing optically pure (+)-ambrisentan and (+)-darusentan | 申请号 | US201114125054 | 专利类型 | US | 公开（公告）号 | US9040698(B2) | 公开（授权）日 | 2015.05.26 | 申请（专利权）人 | 中国科学院化学研究所 | 发明（设计）人 | Shi Yian;Peng Xianyou;Li Peijun | 主分类号 | C07D239/24 | IPC主分类号 | C07D239/24;C07D239/34;C07D239/60 | 专利有效期 | Method for preparing optically pure (+)-ambrisentan and (+)-darusentan 至Method for preparing optically pure (+)-ambrisentan and (+)-darusentan | 法律状态 | 说明书摘要 | Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a β-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan. |
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