| 专利名称 | Quinazoline derivative and application thereof | 申请号 | US201214241067 | 专利类型 | US | 公开（公告）号 | US9193718(B2) | 公开（授权）日 | 2015.11.24 | 申请（专利权）人 | 中国科学院福建物质结构研究所 | 发明（设计）人 | Lu Canzhong;Yong Jianping | 主分类号 | A61K31/517 | IPC主分类号 | A61K31/517;C07D413/12;C07D413/06 | 专利有效期 | Quinazoline derivative and application thereof 至Quinazoline derivative and application thereof | 法律状态 | 说明书摘要 | This invention provides a class of quinazoline compounds, as represented by formula (I), and their pharmaceutically acceptable salts,;wherein: each of R1 and R2 independently, is selected from H, C1-C6 alkoxy, halo-C1-C6 alkoxy, C1-C6-alkoxy-C1-C6 alkoxy, C3-C8 cycloalkoxy, C3-C8 heterocycloalkoxy containing at least one of heteroatoms selected from N, O, S; Z is —NR4—, C(R5)2, S or —O—, wherein R4 is H or C1-C3 alkyl, R5 is the same or different, selected from H or C1-C3 alkyl; R3 is selected from H, halogen, C1-C6 alkyl, C1-C6 alkoxy or halo-C1-C6 alkyl; n is an integer from 0 to 5. This invention also provides methods of preparation and medical uses of the compounds of formula (I) and their pharmaceutically acceptable salts. These compounds have the activity of inhibiting EGFR-TK, and can be used as drugs for the treatment of protein tyrosine kinase related diseases such as tumors, cancers, etc. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障