| 专利名称 | Crystal structure of amino terminal portion of influenza virus polymerase PA subunit and use thereof | 申请号 | US201013254823 | 专利类型 | US | 公开（公告）号 | US9017960(B2) | 公开（授权）日 | 2015.04.28 | 申请（专利权）人 | 中国科学院生物物理研究所 | 发明（设计）人 | Liu Yingfang;Rao Zihe | 主分类号 | C12Q1/34 | IPC主分类号 | C12Q1/34;C07K14/005;C12N9/12;C40B30/02;G06F19/16;G06F19/00 | 专利有效期 | Crystal structure of amino terminal portion of influenza virus polymerase PA subunit and use thereof 至Crystal structure of amino terminal portion of influenza virus polymerase PA subunit and use thereof | 法律状态 | 说明书摘要 | Present invention discloses the three-dimensional crystal structure of the N-terminus polypeptide of influenza virus polymerase subunit (PA_N of SEQ ID NO:7). PA_N of SEQ ID NO: 1 is residues 1—50 to 150-300 of influenza virus polymerase subunit PA. In the three-dimensional structure, at least 40% of atoms show the same atomic coordinates, compared to that listed in Table 1. Namely, in the three-dimensional structure of influenza virus polymerase subunit PA_N of SEQ ID NO: 7, 40% of atomic coordinates on carbon skeleton of residues of influenza virus polymerase subunit PA_N of SEQ ID NO: 7, show less than or equal to 1.7 ? of average variance, compared to the atomic coordinates listed in Table 1. Present invention also discloses the expression, purification, crystallization methods, and three-dimensional crystal structure of 256 residues in the N-terminus of influenza virus polymerase subunit PA, and applications of the crystal structure of SEQ ID NO: 7 on drug screening and designing. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障