| 专利名称 | PROCESS FOR SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USED IN SAID PROCESS | 申请号 | EP20130819243 | 专利类型 | EP | 公开（公告）号 | EP2876102(B1) | 公开（授权）日 | 2016.12.07 | 申请（专利权）人 | 中国科学院上海有机化学研究所 | 发明（设计）人 | DING, Kuiling;WANG, Xiaoming;WANG, Zheng | 主分类号 | C07C67/34 | IPC主分类号 | C07C67/34;C07C69/73;C07F9/50;C07F15/00 | 专利有效期 | PROCESS FOR SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USED IN SAID PROCESS 至PROCESS FOR SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USED IN SAID PROCESS | 法律状态 | 说明书摘要 | A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of ?-arylamino ±-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of ?-arylamino ±-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障