| 专利名称 | ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF | 申请号 | EP20040738186 | 专利类型 | EP | 公开（公告）号 | EP1640367(B1) | 公开（授权）日 | 2011.02.09 | 申请（专利权）人 | 中国科学院上海药物研究所 | 发明（设计）人 | NAN, FAJUN;LI, JIA;CHEN, YIHUA;ZHANG, YAHUI;GU, MIN;ZHANG, HUAJIE | 主分类号 | A61P25/28 | IPC主分类号 | A61P25/28;C07D217/04;A61P25/00;C07D217/24;C07D417/04 | 专利有效期 | ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF 至ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF | 法律状态 | 说明书摘要 | The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzhermer''s disease, apoplexy and brain ischemic injuries. The compound is represented by the following structure formula: Wherein substituents R 1 can be one, two or three groups optionally selected from the group consisting of H; alkyl; hydroxyl; alkyl substituted by the groups including halogen, alkoxyl or hydroxyl; alkoxyl or alkylamino substituted by the groups including halogen, alkoxyl or hydroxyl; C 2 -C 6 alkenyl substituted by oxygen or amine; C 3 -C 6 cycloalkyl; substituted aryl; benzyl; alkanoyl; alkanoyl substituted by the groups including halogen, alkoxyl or hydroxyl; C 2 -C 6 enoyl; C 3 -C 6 cycloalkanoyl; tert -butoxycarbonyl; benzoyl; benzoyl substituted by one, two or three groups including alkylamino; benzylacyl; benzylacyl substituted by one, two or three groups including alkylamino; thienoyl; adamantylcarbonyl; mandeloyl; alkoxyl; alkylamino; cycloalkoxyl; cycloalkylamino; amino; acylamino; alkyloxycarbonyl; cycloalkoxycarbonyl; alkanoylxy; alkanoylamino; cycloalkyanoylxy; cycloalkanoylamino; ureido; urenylene; alkanoyl; nitro; carboxyl; R 2 is H; alkyl; alkyl or C 1 -C 4 cycloalkyl substituted by the groups including halogen, alkoxyl or hydroxyl; C 2 -C 6 alkenyl; aryl; substituted aryl; X is H, CH 2 , NH, O, or S; Y is CH, or N. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障