| 专利名称 | SCHWEFELHALTIGE NAPHTHOYLIMIDDERIVATE | 申请号 | DE20046024386T | 专利类型 | DE | 公开（公告）号 | DE602004024386(D1) | 公开（授权）日 | 2010.01.14 | 申请（专利权）人 | 中国科学院上海药物研究所 | 发明（设计）人 | QIAN, XUHONG;LI, YONGGANG;XU, YUFANG;DING, JIAN;LIN, LIPING;MIAO, ZEHONG;ZHU, HONG;QU, BAOYUAN | 主分类号 | C07D495/06 | IPC主分类号 | C07D495/06;A61K31/473;A61K31/4743;A61K31/4745;A61P35/00;C07D221/06;C07D221/14;C07D405/12;C07D513/06 | 专利有效期 | SCHWEFELHALTIGE NAPHTHOYLIMIDDERIVATE 至SCHWEFELHALTIGE NAPHTHOYLIMIDDERIVATE | 法律状态 | 说明书摘要 | The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent. |
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