Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity

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专利名称 Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity 申请号 US20090865843 专利类型 US 公开(公告)号 US8722634(B2) 公开(授权)日 2014.05.13 申请(专利权)人 中国科学院上海药物研究所 发明(设计)人 YE YANG;TAN MINJIA;KE CHANGQIANG;CHEN TONG;LI XIQIANG;KRAEGEN EDWARD;YE JIMING;JAMES DAVID;COONEY GREGORY 主分类号 A61K31/70 IPC主分类号 A61K31/70 专利有效期 Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity 至Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity 法律状态 说明书摘要 The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.

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