| 专利名称 | Pyrimidinyl-propionic acid derivatives and their use as PPAR agonists | 申请号 | US20100682530 | 专利类型 | US | 公开（公告）号 | US8513233(B2) | 公开（授权）日 | 2013.08.20 | 申请（专利权）人 | 中国科学院上海药物研究所 | 发明（设计）人 | SHEN JIANHUAMEI CHANGLINJIANG HUALIANGDAI BINYE YANGLIANGXIONG XISHANTANG JINGFU LIL | 主分类号 | A61K31/55 | IPC主分类号 | A61K31/55;A61K31/506;A61K31/5377;C07D403/04;C07D403/14;C07D413/14 | 专利有效期 | Pyrimidinyl-propionic acid derivatives and their use as PPAR agonists 至Pyrimidinyl-propionic acid derivatives and their use as PPAR agonists | 法律状态 | 说明书摘要 | The present invention disclosed compounds of Structural Formula (I), and enantiomer, racemic body, pharmaceutically acceptable salts, solvates or hydrates thereof, wherein variable groups are as defined within, as well as methods for preparing such compounds. The compounds are useful as PPARgamma agonist, through activating PPAR-RXR heterodimers that interacts with specific DNA response elements within promoter regions of target gene, particularly in the treatment and prevention of polycystic kidney and cancer. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障