Two types of crystalline of pinocembrin, their preparation and their use for manufacture of pharmaceutical compositions

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专利名称 Two types of crystalline of pinocembrin, their preparation and their use for manufacture of pharmaceutical compositions 申请号 US200813128896 专利类型 US 公开(公告)号 US8399511(B2) 公开(授权)日 2013.03.19 申请(专利权)人 中国科学院上海药物研究所 发明(设计)人 DU GUANHUALV YANGWU SONGWANG KECHANG YINGYANG ZHIHONGTONG YUANFENGGAO ME 主分类号 A61K31/353 IPC主分类号 A61K31/353;C07D311/32 专利有效期 Two types of crystalline of pinocembrin, their preparation and their use for manufacture of pharmaceutical compositions 至Two types of crystalline of pinocembrin, their preparation and their use for manufacture of pharmaceutical compositions 法律状态 说明书摘要 Two crystalline forms of pinocembrin of formula (I):αandβ, their preparation and their use for manufacture of pharmaceutical compositions. There exists difference between them in bioavailability. They are used for treating and preventing cerebral ischemic diseases by protective action of neurovascular unit, and enhancing blood drug level in vivo.

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