| 专利名称 | Recombinant flagellin protein and preparation and use thereof | 申请号 | US201013122409 | 专利类型 | US | 公开（公告）号 | US8449891(B2) | 公开（授权）日 | 2013.05.28 | 申请（专利权）人 | 中国科学院武汉病毒研究所 | 发明（设计）人 | YAN HUIMINLIU FANGYANG JINGY | 主分类号 | C07K1/00 | IPC主分类号 | C07K1/00;A61K39/00;A61K39/02;A61K39/112;A61K39/38;C07K14/00;C07K17/00 | 专利有效期 | Recombinant flagellin protein and preparation and use thereof 至Recombinant flagellin protein and preparation and use thereof | 法律状态 | 说明书摘要 | The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is the region from 180 to 400 amino acid of the flagellin protein, and the proteins include FliCDelta190-278, FliCDelta220-320 or FliCDelta180-400. The method of preparing said protein, comprising introducing a deletion into the hypervariable region of the flagellin protein. First constructed the flagellin protein recombinant plasmid, and then used it as template to construct the flagellin deletion cloning, and expressed and purified. The present invention also provides the use of the recombinant flagellin protein as adjuvant. The recombinant flagellin protein in present invention decreases the potential risks it may have, and decreases its antigenicity and immunogenicity and the inflammatory response induced by it, through deleting its main areas of immunogenicity and antigen activity. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障