| 专利名称 | Use of acacetin and related compounds as potassium channel inhibitors | 申请号 | US20100876621 | 专利类型 | US | 公开（公告）号 | US8461198(B2) | 公开（授权）日 | 2013.06.11 | 申请（专利权）人 | 中国科学院上海药物研究所 | 发明（设计）人 | LI GUI-RONGLAU CHU-PAKQIN GUO-WEIWANG HONG-BIN | 主分类号 | C07D311/26 | IPC主分类号 | C07D311/26;A61K31/353 | 专利有效期 | Use of acacetin and related compounds as potassium channel inhibitors 至Use of acacetin and related compounds as potassium channel inhibitors | 法律状态 | 说明书摘要 | This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.Ach). |
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