Amide compounds, their pharmaceutical compositions, their preparation method and their uses

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专利名称 Amide compounds, their pharmaceutical compositions, their preparation method and their uses 申请号 US200913123455 专利类型 US 公开(公告)号 US8410094(B2) 公开(授权)日 2013.04.02 申请(专利权)人 中国科学院上海药物研究所 发明(设计)人 LONG YAQIUFAN XINGFENG DONGZHICHEN LICHEN RENHA 主分类号 C07D451/04 IPC主分类号 C07D451/04;A61K31/46 专利有效期 Amide compounds, their pharmaceutical compositions, their preparation method and their uses 至Amide compounds, their pharmaceutical compositions, their preparation method and their uses 法律状态 说明书摘要 The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD).

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