| 专利名称 | Pyrazolopyramidinone derivatives, their preparation and their use | 申请号 | EP20100171901 | 专利类型 | EP | 公开（公告）号 | EP2253632(B1) | 公开（授权）日 | 2012.05.23 | 申请（专利权）人 | 中国科学院上海药物研究所 | 发明（设计）人 | TIAN GUANGHUILAI SHUNANWANG ZHENZHU YICHEN XINJIANJI YURONGZHANG JINFENGJIN WEIXILV HEPINGLIU JINPINGWANG WEIJI RUYUNSHEN JINGSHA | 主分类号 | C07D487/04 | IPC主分类号 | C07D487/04;A61K31/519;A61P15/10 | 专利有效期 | Pyrazolopyramidinone derivatives, their preparation and their use 至Pyrazolopyramidinone derivatives, their preparation and their use | 法律状态 | 说明书摘要 | The invention discloses a series of pyrazolopyrimidinone derivatives, which have the following chemical structure, their preparation methods and use, It has been proved by pharmacological experiment that the said pyrazolopyrimidinone derivatives have high inhibitory activity against PDE5, and parts of them have a much stronger potency against PDE5 than against PDE6. Most of the compounds show low toxicity. The pyrazolopyrimidinone derivatives can be used in clinics for the palliative or curative treatment of symptoms or diseases relating to cardiovascular system, urinary system, especially for the palliative or curative treatment of erectile dysfunction. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障