专利名称 | METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR | 申请号 | EP20060791004 | 专利类型 | EP | 公开(公告)号 | EP1941887(B1) | 公开(授权)日 | 2012.01.18 | 申请(专利权)人 | 中国科学院高能物理研究所 | 发明(设计)人 | ZHAO YULIANGCHEN CHUNYINGXING GENGME | 主分类号 | A61K33/24 | IPC主分类号 | A61K33/24;A61K31/28;A61P35/00 | 专利有效期 | METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR 至METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR | 法律状态 | 说明书摘要 | This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C 2m (OH) x , wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C 2m O x H y . Comparing to the clinical anticancer drugs such as Pacilitaxel, Cyclophusphamide, and Cisplatin, metallofullerol of M@C 2m (OH) x or M@C 2m O x H y has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility. |
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