METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR

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专利名称 METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR 申请号 EP20060791004 专利类型 EP 公开(公告)号 EP1941887(B1) 公开(授权)日 2012.01.18 申请(专利权)人 中国科学院高能物理研究所 发明(设计)人 ZHAO YULIANGCHEN CHUNYINGXING GENGME 主分类号 A61K33/24 IPC主分类号 A61K33/24;A61K31/28;A61P35/00 专利有效期 METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR 至METALLO-FULLERENOLS AND ITS APPLICATION IN PREPARATION OF MEDICINES FOR INHIBITING THE GROWTH OF TUMOUR 法律状态 说明书摘要 This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C 2m (OH) x , wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C 2m O x H y . Comparing to the clinical anticancer drugs such as Pacilitaxel, Cyclophusphamide, and Cisplatin, metallofullerol of M@C 2m (OH) x or M@C 2m O x H y has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility.

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