| 专利名称 | Quinolyl organic germanium ester and the synthesis method thereof | 申请号 | US20050148738 | 专利类型 | US | 公开（公告）号 | US2005282795 | 公开（授权）日 | 2005.12.22 | 申请（专利权）人 | 中国科学院长春应用化学研究所 | 发明（设计）人 | QU XIAOGANG (CN); SHANGGUAN GUOQIANG (CN) | 主分类号 | (IPC1-7): A61K31/555 | IPC主分类号 | (IPC1-7): A61K31/555;C07F7/30 | 专利有效期 | Quinolyl organic germanium ester and the synthesis method thereof 至Quinolyl organic germanium ester and the synthesis method thereof | 法律状态 | 说明书摘要 | The present invention relates to compounds of quinolyl organic germanium ester having the following Formula 1 and the synthesis methods thereof. R1 and R2 are defined in the specification. Organic germanium acyl chloride and 8-hydroxylquinoline were used as the starting raw materials. Displacement reaction was carried out at 0-40 DEG C., followed by hydrolysis reaction and then by changing the solvent, water soluble quinolyl organic germanium ester was finally obtained. The quinolyl organic germanium ester possesses better water solubility and fat solubility. Due to the existence of both drug active group (organic germanium part) and drug recognizing group (quinoline part) in the structure of the quinolyl organic germanium ester, the compound is expected to develop a novel kind of anti-tumor dru |
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