| 专利名称 | Production process for 16-dehydropregnenoneol and its analogs | 申请号 | US20050561164 | 专利类型 | US | 公开（公告）号 | US2006166955 | 公开（授权）日 | 2006.07.27 | 申请（专利权）人 | 中国科学院上海有机化学研究所 | 发明（设计）人 | TIAN WEISHENG (CN);XU XIN (CN);LIU SHANSHAN (CN);SHEN JUNWEI (CN);WU XIUJING (CN) | 主分类号 | A61K31/56 | IPC主分类号 | A61K31/56;C07J5/00;C07J7/00;C07J71/00 | 专利有效期 | Production process for 16-dehydropregnenoneol and its analogs 至Production process for 16-dehydropregnenoneol and its analogs | 法律状态 | 说明书摘要 | The present invention relates to a clean process for the degradation of steroidal sapogenin to produce 16-dehydropregnenolone and its analogs. The pure or the crude pseudo steroidal sapogenin, derived from steroidal sapogenin, dissolved in organic solvent, reacts with hydrogen peroxide with or without metal compound and acid as catalyst, and the crude products directly go through elimination and hydrolization in the presence of base to give 16-Dehydropregnenolone or its analog, accompanied with the other product 4R(or S)-methyl-5-hydroxy-pentate, which is converted to 4R(or S)-methyl-delta-pentyl lactone after acidification and extraction from the water layer. This technology improved the utilizing degree of steroidal sapogenin, improved the yield, and cleared up the chromium pollution in the former technique. In a word, the method disclosed in this invention is more suitable for manufacture. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障