| 专利名称 | Gutless adenovirus vector and the construction method thereof | 申请号 | US20040559008 | 专利类型 | US | 公开（公告）号 | US2007077226 | 公开（授权）日 | 2007.04.05 | 申请（专利权）人 | 中国科学院上海生命科学研究院 | 发明（设计）人 | LIU XINYUAN (CN);PEI ZIFEL (CN);LI BINGHUA (CN);GU JINFA (CN);ZOU WEIGUO (CN);SUN LANYING (CN) | 主分类号 | A61K48/00 | IPC主分类号 | A61K48/00;A61P35/00;C12N7/01;C12N15/861;A61K38/00 | 专利有效期 | Gutless adenovirus vector and the construction method thereof 至Gutless adenovirus vector and the construction method thereof | 法律状态 | 说明书摘要 | The present invention disclosed a kind of gutless adenovirus vector and the construction method thereof. Two structural independent but functional related cassettes, the trans-activator (TA) and anti-tumor cassette, are both carried by the gutless vector. hTERT promoter restricts the expression of TA only in tumor cells, and RU486, associated with TA, regulates the expression of interesting gene: when needed, add the RU486 and the gene expression is on, and when not needed, remove the RU486 and the gene expression is off. Tumor-specificity and small molecule regulation of the vector spare the toxicity to the normal tissue caused by the foreign gene product and endow the gene's long lifetime expression in vivo. The vector of the present invention shows many advantages over traditional adenovirus vectors in targeting, gene regulation and expression lifetime. |
1、源头对接，价格透明
2、平台验证，实名审核
3、合同监控，代办手续
4、专员跟进，交易保障