| 专利名称 | DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides | 申请号 | US19980157397 | 专利类型 | US | 公开（公告）号 | US6165765 | 公开（授权）日 | 2000.12.26 | 申请（专利权）人 | 中国科学院上海生物化学研究所 | 发明（设计）人 | HONG GUOFAN (CN); HUANG WEI-HUA (CN) | 主分类号 | C12N9/12 | IPC主分类号 | C12N9/12;C12Q1/68;C12P19/34 | 专利有效期 | DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides 至DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides | 法律状态 | 说明书摘要 | The invention relates to genetical modification of DNA polymerase to reduce its innate selective sequence-related discrimination against incorporation of fluorescent dye-labeled ddCTP and ddATP in the enzymatic reaction for preparation of samples for automated florescent dye-labeled terminator DNA sequencing. The modified DNA polymerases are more resistant to heat inactivation and are more effective in dideoxynucleotide incorporation than current DNA polymerases. |
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