| 专利名称 | Triplex forming oligonucleotides and their use in anti-HBV | 申请号 | US20000529812 | 专利类型 | US | 公开（公告）号 | US6682930(B1) | 公开（授权）日 | 2004.01.27 | 申请（专利权）人 | 中国科学院上海生物化学与细胞生物学研究所 | 发明（设计）人 | LU CHANGDE (CN) | 主分类号 | C07H21/04 | IPC主分类号 | C07H21/04;C12N15/09;A61P31/00;A61K38/0020060101C;C12N15/86;C12N15/85;C12Q1/68;C07H21/0020060101C;C07H21/0020060101A;C12P19/34;A61P31/20;C12N15/11320100101C;A61K48/00;C12N15/11320100101A;A61K31/711;A61K38/0020060101A | 专利有效期 | Triplex forming oligonucleotides and their use in anti-HBV 至Triplex forming oligonucleotides and their use in anti-HBV | 法律状态 | 说明书摘要 | A type of new triplex forming oligonucleotide (TFO) which can form triplex DNA when bound to two similar fragments of homopolypurine/homopolypyrimidine sequences. TFOs were designed according to the above structure to bind the DR region and pre-S gene promoter region of HBV, respectively. The 3'' end of the TFOs can be monophosphorylated or otherwise chemically modified to increase their stability. Cellular experiments prove that these TFOs can be used as drugs to inhibit HBV and treat hepatitis B. TFO and anti-sense oligonucleotide sequences from the DR or pre-S promoter region of HBV can together bind to target RNA sequences and form a (DNA)2:RNA hetero-triplex structure that results in the more efficient inhibition of HBV. |
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