| 专利名称 | Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth | 申请号 | US20060992249 | 专利类型 | US | 公开（公告）号 | US8124657(B2) | 公开（授权）日 | 2012.02.28 | 申请（专利权）人 | 中国科学院高能物理研究所 | 发明（设计）人 | ZHAO YULIANGCHEN CHUNYINGXING GENGME | 主分类号 | A61K31/047 | IPC主分类号 | A61K31/047;C07C35/00 | 专利有效期 | Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth 至Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth | 法律状态 | 说明书摘要 | This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C2m(OH)x, wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C2mOxHy. Comparing to the clinical anticancer drugs such as Paclitaxel, Cyclophosphamide, and Cisplatin, metallofullerol of M@C2m(OH)x or M@C2mOxHy has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility. |
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